Policaptil Gel Retard® reduces body weight and improves insulin sensitivity in obese subjects
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Keywords
Abstract
Policaptil Gel Retard® (PGR), a natural fiber-based molecule, has been shown to prevent weight gain and ameliorate insulin-resistance indices in obese children and adolescents. The aim of this study was to compare the effects of 12 weeks of low calories and low glycemic index (LC-LGI) diet associated or not with the intake of PGR on anthropometric, bioimpedance, and metabolic parameters. Data from 20 obese adult subjects (10 per group) were analyzed. An LC-LGI diet with or without PGR intake reduced weight, BMI, and waist circumference. PGR intake elicited a reduction in fasting plasma insulin and insulin resistance index together with an improvement in insulin sensitivity.
Riferimenti bibliografici
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Fornari, E., Morandi, A., Piona, C., Tommasi, M., Corradi, M. and Maffeis, C., (2020). Policaptil gel retard intake reduces post-prandial triglycerides, ghrelin and appetite in obese children: a clinical trial. Nutrients 12(1): 214. 10.3390/nu12010214
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Greco, C.M., Garetto, S., Montellier, E., Liu, Y., Chen, S., Baldi, P., Sassone-Corsi, P. and Lucci, J., 2020. A non-pharmacological therapeutic approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced dysfunctions encompassed by metabolic syndrome. Scientific Reports 10(1): 12915. 10.1038/s41598-020-69469-y
Guarino, G., Della Corte, T., Strollo, F. and Gentile, S., 2021. Policaptil gel retard in adult subjects with the metabolic syndrome: efficacy, safety, and tolerability compared to metformin. Diabetes & Metabolic Syndrome 15(3): 901–907. 10.1016/J.DSX.2021.03.032
Katz, A., Nambi, S.S., Mather, K., Baron, A.D., Follmann, D.A., Sullivan, G. and Quon, M.J., 2000. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. The Journal of Clinical Endo-crinology & Metabolism 85(7): 2402–2410. 10.1210/jcem.85.7.6661
Laakso, M. and Kuusisto, J., 2014. Insulin resistance and hyper-glycaemia in cardiovascular disease development. Nature Reviews Endocrinology 10(5): 293–302. 10.1038/nrendo.2014.29
Matthews, D.R., Hosker, Rudenski, Naylor, Treacher, and Turner, 1985. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7): 412–419. 10.1007/BF00280883SINU, 2019.
Livelli Di Assunzione Di Riferimento Di Nutrienti Ed Energia per La Popolazione Italiana (LARN). Available at: https://sinu.it/larn/
Stagi, S., Lapi, E., Seminara, S., Pelosi, P., Del Greco, P., Capirchio, L., Strano, M., Giglio, S., Chiarelli, F. and De Martino, M., 2016. Policaptil gel retard® significantly lowered body mass index and hyperinsulinemia, and reduced the risk of diabetes mellitus type 2 (DM2) in children and adolescents with obesity, family history and DM2. Pediatriya 56(2): 38–45. 10.1186/s13052-015-0109-7
Stagi, S., Ricci, F., Bianconi, M., Sammarco, M.A., Municchi, G., Toni, S., Lenzi, L., Verrotti, A. and de Martino, M., 2017. Retrospective evaluation of metformin and/or metformin plus a new polysaccharide complex in treating severe hyperinsulinism and insulin resistance in obese children and adolescents with metabolic syndrome. Nutrients 9(5): 1–17. 10.3390/nu9050524
Weickert, M.O. and Pfeiffer, A.F.H., 2008. Metabolic effects of dietary fiber consumption and prevention of diabetes. Journal of Nutrition 138(3) 439–442. 10.1093/jn/138.3.439
WHO, 2015. Obesity: preventing and managing the global epidemic. WHO.
Ceriello, A., 2003. New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care 54(1), 1–7. 10.2337/diacare.26.5.1589
Dwyer, J.T., Melanson, K.J., Sriprachy-anunt, U., Cross, P. and Wilson, M., 2000. Dietary treatment of obesity. South Dart-mouth (MA). Endotext. MDText.com, Inc.
Esparza-Ros, F., Vaquero-Cristóbal, R. and Marfell-Jones, M., 2019. International standards for anthropometric assessment (2019). p. 115. Available at: https://www.researchgate.net/publication/236891109_International_Standards_for_Anthropometric_Assessment
Finer, N., 2015. Medical consequences of obesity. Medicine (United Kingdom) 43(2): 88–93. 10.1016/j.mpmed.2014.11.003
Fornari, E., Morandi, A., Piona, C., Tommasi, M., Corradi, M. and Maffeis, C., (2020). Policaptil gel retard intake reduces post-prandial triglycerides, ghrelin and appetite in obese children: a clinical trial. Nutrients 12(1): 214. 10.3390/nu12010214
Frühbeck, G., Toplak, H., Woodward, E., Yumuk, V., Maislos, M. and Oppert, J.M., 2013. Obesity: the gateway to ill health–an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obesity Facts 6(2): 117–120. 10.1159/000350627
Greco, C.M., Garetto, S., Montellier, E., Liu, Y., Chen, S., Baldi, P., Sassone-Corsi, P. and Lucci, J., 2020. A non-pharmacological therapeutic approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced dysfunctions encompassed by metabolic syndrome. Scientific Reports 10(1): 12915. 10.1038/s41598-020-69469-y
Guarino, G., Della Corte, T., Strollo, F. and Gentile, S., 2021. Policaptil gel retard in adult subjects with the metabolic syndrome: efficacy, safety, and tolerability compared to metformin. Diabetes & Metabolic Syndrome 15(3): 901–907. 10.1016/J.DSX.2021.03.032
Katz, A., Nambi, S.S., Mather, K., Baron, A.D., Follmann, D.A., Sullivan, G. and Quon, M.J., 2000. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. The Journal of Clinical Endo-crinology & Metabolism 85(7): 2402–2410. 10.1210/jcem.85.7.6661
Laakso, M. and Kuusisto, J., 2014. Insulin resistance and hyper-glycaemia in cardiovascular disease development. Nature Reviews Endocrinology 10(5): 293–302. 10.1038/nrendo.2014.29
Matthews, D.R., Hosker, Rudenski, Naylor, Treacher, and Turner, 1985. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7): 412–419. 10.1007/BF00280883SINU, 2019.
Livelli Di Assunzione Di Riferimento Di Nutrienti Ed Energia per La Popolazione Italiana (LARN). Available at: https://sinu.it/larn/
Stagi, S., Lapi, E., Seminara, S., Pelosi, P., Del Greco, P., Capirchio, L., Strano, M., Giglio, S., Chiarelli, F. and De Martino, M., 2016. Policaptil gel retard® significantly lowered body mass index and hyperinsulinemia, and reduced the risk of diabetes mellitus type 2 (DM2) in children and adolescents with obesity, family history and DM2. Pediatriya 56(2): 38–45. 10.1186/s13052-015-0109-7
Stagi, S., Ricci, F., Bianconi, M., Sammarco, M.A., Municchi, G., Toni, S., Lenzi, L., Verrotti, A. and de Martino, M., 2017. Retrospective evaluation of metformin and/or metformin plus a new polysaccharide complex in treating severe hyperinsulinism and insulin resistance in obese children and adolescents with metabolic syndrome. Nutrients 9(5): 1–17. 10.3390/nu9050524
Weickert, M.O. and Pfeiffer, A.F.H., 2008. Metabolic effects of dietary fiber consumption and prevention of diabetes. Journal of Nutrition 138(3) 439–442. 10.1093/jn/138.3.439
WHO, 2015. Obesity: preventing and managing the global epidemic. WHO.
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Pubblicato
Jun 14, 2022
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Come citare
Centorame, G., Baldassarre, M. P. A., Di Dalmazi, G., Gambacorta, F., Febo, F., Consoli, A., & Formoso, G. (2022). Policaptil Gel Retard® reduces body weight and improves insulin sensitivity in obese subjects. Italian Journal of Food Science, 34(2), 74-79. https://doi.org/10.15586/ijfs.v34i2.2204
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Come citare
Centorame, G., Baldassarre, M. P. A., Di Dalmazi, G., Gambacorta, F., Febo, F., Consoli, A., & Formoso, G. (2022). Policaptil Gel Retard® reduces body weight and improves insulin sensitivity in obese subjects. Italian Journal of Food Science, 34(2), 74-79. https://doi.org/10.15586/ijfs.v34i2.2204